S100 proteins structure functions and pathology

摘要: S100 proteins regulate intracellular processes such as cell growth and motility, cycle regulation, transcription differentiation. Twenty members have been identified so far, altogether, represent the largest subgroup in EF-hand Ca2+ -binding protein family. A unique feature of these is that individual are localized specific cellular compartments from which some able to relocate upon activation, transducing signal a temporal spacial manner by interacting with different targets for each protein. Some even secreted cells exerting extracellular, cytokine-like activities partially via surface receptor RAGE (receptor advanced glycation endproducts) paracrine effects e.g. on neurons, promoting their survival during development or after injury. Another important aspect 14 bona fide genes found gene cluster human chromosome 1q21 where number chromosomal abnormalities occur. This results deregulated expression associated neoplasias. Recently, received increasing attention due close association several diseases including cardiomyopathy, neurodegenerative disorders cancer. They also proven be valuable diagnostic diseases, predictive markers improving clinical management, outcome patients considered having potential drug improve therapies.