Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine-seeking behaviour in rats

摘要: The psychostimulant methamphetamine (METH) is an addictive illicit drug. Systemic administration of the neuropeptide oxytocin modulates METH-related reward and METH-seeking behaviour. Recent findings demonstrated a reduction in METH-induced by into nucleus accumbens (NAc) core. It not known, however, if acts this region to reduce relapse Using drug reinstatement paradigm rats experienced at METH self-administration, we aimed determine whether pre-treatment within NAc core would use could be reversed co-administration receptor (OTR) antagonist desGly-NH2,d(CH2)5[D-Tyr2,Thr4]OVT. Male Sprague-Dawley underwent surgery implant intravenous jugular vein catheter bilateral microinjection cannulae Rats were then trained self-administer (0.1 mg/kg/infusion) lever press during 2-hour fixed ratio 1 scheduled sessions for 20 days. Following extinction activity, effect microinjecting saline, (0.5 pmol, 1.5 4.5 pmol) or (1.5 desGly-NH2,d(CH2)5[D-Tyr2,Thr4]OVT (1 nmol, 3 nmol) (500 nl/side) was examined on METH-primed mg/kg, i.p.) drug-seeking Our results showed directly administered decreased dose-dependent manner. Co-administration selective OTR did specifically reverse inhibitory effects priming, suggesting mediation receptors other than OTR. These highlight important modulatory seeking.