The treatment of severe falciparum malaria.

摘要: Abstract In severe falciparum malaria there is a pathophysiological cascade beginning with changes in the parasitized red blood cells which induce intermediate effects, turn contributing to dysfunction of several organs. A low serum albumin common but often unrecognized finding may contribute oedema especially lung and brain. The only irreversible complication acute respiratory distress syndrome, manifested by cyanosis rapid breathing, basically distinct from pulmonary caused therapeutic overhydration. pathophysiology be complex treatment simple. Drugs, other than antimalarials, are rarely needed. Guidelines for cholorquine or quinine dosage disease proposed; each drug given at dose 5 10 mg/kg ml/kg fluid as an intravenous infusion four hours frequency dosing every 12 24 hours. When has been brought under control should changed oral route.