Copper-Mediated Fluorination of Aryl Iodides
作者： Patrick S. Fier , John F. Hartwig
DOI: 10.1021/JA304410X
关键词: Aryl 、 Halogenation 、 Chemistry 、 Fluoride 、 Combinatorial chemistry 、 Reagent 、 Reactivity (chemistry) 、 Organic chemistry 、 Cationic polymerization 、 Silver fluoride 、 Reductive elimination
摘要: The synthesis of aryl fluorides has been studied intensively because the importance in pharmaceuticals, agrochemicals, and materials. stability, reactivity, biological properties can be distinct from those corresponding arenes. Methods for fluorides, however, are limited. We report conversion a diverse set iodides to fluorides. This reaction occurs with cationic copper reagent silver fluoride. Preliminary results suggest this is enabled by facile reductive elimination arylcopper(III)
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