Building Block Approaches to Aliphatic Organofluorine Compounds

作者: Jonathan M. Percy

DOI: 10.1007/3-540-69197-9_4

关键词: CarbonMoleculeCombinatorial chemistryBlock (periodic table)FluorineOrganofluorine compoundsChemistry

摘要: This review deals with general and significant developments in the area of building block chemistry lightly-fluorinated aliphatic compounds, that is, those contain one, two, or three, fluorine atoms. For purposes review, blocks are small readily-available materials already They classified according to number carbon atoms supplied target molecule, rather than Finally, certain fluorinated motifs which may be generated easily, then transformable useful ways, discussed.

参考文章(366)
Yoshitoshi Kodama, Masato Okumura, Noriko Yanabu, Takeo Taguchi, Synthesis of β-amino-α,α-difluoroketones by reactions of 1,1-difluorovinyl methyl ethers with N-acyliminium intermediates Tetrahedron Letters. ,vol. 37, pp. 1061- 1064 ,(1996) , 10.1016/0040-4039(95)02348-8
Ahmed Abouabdellah, Jean-Pierre Bégué, Danièle Bonnet-Delpon, Jean-Charles Gantier, Truong Thi Thanh Nga, Truong Dinh Thac, Synthesis and in vivo antimatarial activity of 12α-trifluoromethyl-hydroartemisinin Bioorganic & Medicinal Chemistry Letters. ,vol. 6, pp. 2717- 2720 ,(1996) , 10.1016/S0960-894X(96)00488-X
David B. Berkowitz, MariJean Eggen, Quanrong Shen, Darby G. Sloss, Synthesis of (α,α-difluoroalkyl)phosphonates by displacement of primary triflates Journal of Organic Chemistry. ,vol. 58, pp. 6174- 6176 ,(1993) , 10.1021/JO00075A005
Peter R. Bernstein, Bruce C. Gomes, Benedict J. Kosmider, Edward P. Vacek, Joseph C. Williams, Nonpeptidic Inhibitors of Human Leukocyte Elastase. 6. Design of a Potent, Intratracheally Active, Pyridone-Based Trifluoromethyl Ketone Journal of Medicinal Chemistry. ,vol. 38, pp. 212- 215 ,(1995) , 10.1021/JM00001A028
Akira Otaka, Kengo Miyoshi, Terrence R Burke, Peter P Roller, Hideki Kubota, Hirokazu Tamamura, Nobutaka Fujii, Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues Tetrahedron Letters. ,vol. 36, pp. 927- 930 ,(1995) , 10.1016/0040-4039(94)02374-K
Alberto Arnone, Pierfrancesco Bravo, Fiorenza Viani, Matteo Zanda, Giancarlo Cavicchio, Marcello Crucianelli, gem-Difluoro-cyclohexene and -cycloheptene derivatives through cyclization of gem-difluoroallyl radicals Journal of Fluorine Chemistry. ,vol. 76, pp. 169- 173 ,(1996) , 10.1016/0022-1139(95)03339-4
Yoshiro Kobayashi, Tsutomu Morikawa, Atsuko Yoshizawa, Takeo Taguchi, A stereospecific synthesis of conjugated fluorodienes by a ring-opening reaction of gem-difluorocyclopropane derivatives Tetrahedron Letters. ,vol. 22, pp. 5297- 5300 ,(1981) , 10.1016/S0040-4039(01)92485-2
A. Abouabdellah, L. Boros, F. Gyenes, J.T. Welch, New applications of fluorinated building blocks Journal of Fluorine Chemistry. ,vol. 72, pp. 255- 259 ,(1995) , 10.1016/0022-1139(94)00416-D