Comparing the relationship of Taxol-based chemotherapy response with P-glycoprotein and lung resistance-related protein expression in non-small cell lung cancer.

摘要: Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections the biopsy specimens detect Pgp and LPR expressions in 40 patients advanced NSCLC before chemotherapy. The evaluated by clinical radiological methods third month after completion treatment. No significant differences prognostic factors (age, sex, body weight loss, performance status, tumor size, stage, type) found between 20 good poor responses. incidence difference positive responses significant, however, LRP not. We concluded that related but not expression.