Evaluation of modern pathological criteria for positive margins in radical prostatectomy specimens and their use for predicting biochemical recurrence

摘要: OBJECTIVES To assess the interpretation of modern criteria for evaluating surgical margins (SMs), by examining incidence positive SMs (PSMs) and subsequent biochemical recurrence in a single-surgeon series radical prostatectomy (RP) at two institutions, as determining PSMs after RP are subject to individual interpretation, this might explain some variability rates with different PSMs. PATIENTS AND METHODS We reviewed 301 consecutive perineal RPs one surgeon (T.K.) Emory University Hospital (EUH) Medical South Carolina (MUSC), each pathology department using evaluate SMs. The SM status (BCR) were analysed, latter defined prostate-specific antigen level ≥0.2 ng/mL. RESULTS There 158 EUH followed 143 MUSC. reported 39 patients (24.7%) EUH, whereas six (4.2%) overall BCR similar between groups, but within margin-positive cases was 100% MUSC vs 25.6% (P < 0.01). presence tumour <1 mm from margin did not increase rate compared those obvious negative (P = 0.731). CONCLUSION In series, same resulted significantly PSM institutions. Although reason these differences is difficult determine, study shows clearly that 1 mm should be classified margin-positive.