Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

摘要: Monoclonal antibodies are a possible adjunct to vaccination and drugs in treatment of influenza virus infection. However questions remain whether small animal models accurately predict efficacy humans. We have established the pig, large natural host for influenza, with many physiological similarities humans, as robust model testing monoclonal antibodies. show that strongly neutralizing antibody (2-12C) against hemagglutinin head administered prophylactically at 15 mg/kg reduced viral load lung pathology after pandemic H1N1 challenge. A lower dose 1 2-12C or DNA plasmid encoded version 2-12C, lungs, but not shedding nasal swabs. propose pig will be useful candidate emerging delivery platforms prior human trials.