Discrete and continuum models for the evolutionary and spatial dynamics of cancer: a very short introduction through two case studies

作者: T. Lorenzi , F. R. Macfarlane , C. Villa

DOI: 10.1007/978-3-030-46306-9_22

关键词: Partial differential equationNonlinear systemEvolutionary dynamicsStatistical physicsRandom walkContinuum (measurement)Cytotoxic TherapyComputer science

摘要: We give a very short introduction to discrete and continuum models for the evolutionary spatial dynamics of cancer through two case studies: model cells under cytotoxic therapy mechanical interaction between healthy during tumour growth. First we develop models, whereby single are described set rules that result in branching random walks. Then present corresponding which formulated terms non-local nonlinear partial differential equations, summarise key properties their solutions. Finally, carry out numerical simulations construct solutions models. The biological implications results obtained briefly discussed.

参考文章(112)
Luigi Preziosi, None, Cancer Modelling and Simulation CRC Press. pp. 426- 426 ,(2003) , 10.1201/9780203494899
Kevin Painter, Thomas Hillen, Volume-filling and quorum-sensing in models for chemosensitive movement Canadian Applied Mathematics Quarterly. ,vol. 10, pp. 501- 544 ,(2002)
Christophe Deroulers, Marine Aubert, Mathilde Badoual, Basil Grammaticos, Modeling tumor cell migration: From microscopic to macroscopic models Physical Review E. ,vol. 79, pp. 031917- ,(2009) , 10.1103/PHYSREVE.79.031917
Tommaso Lorenzi, Rebecca H. Chisholm, Laurent Desvillettes, Barry D. Hughes, Dissecting the dynamics of epigenetic changes in phenotype-structured populations exposed to fluctuating environments Journal of Theoretical Biology. ,vol. 386, pp. 166- 176 ,(2015) , 10.1016/J.JTBI.2015.08.031
Polina Kurbatova, Samuel Bernard, Nikolai Bessonov, Fabien Crauste, Ivan Demin, Charles Dumontet, Stephan Fischer, Vitaly Volpert, HYBRID MODEL OF ERYTHROPOIESIS AND LEUKEMIA TREATMENT WITH CYTOSINE ARABINOSIDE Siam Journal on Applied Mathematics. ,vol. 71, pp. 2246- 2268 ,(2011) , 10.1137/100815517