How Does Interleukin 15 Contribute to the Pathogenesis of HTLV Type 1-Associated Myelopathy/Tropical Spastic Paraparesis?

摘要: HTLV-1 is the etiological agent of a neurological disease named HAM/TSP that has clinical characteristics similar to those multiple sclerosis (MS). The PBMC obtained from patients undergo spontaneous proliferation in absence addition any exogenous cytokines an ex vivo culture. This been thought be due T cells. It was demonstrated this is, part, production IL-2 and its receptor (IL-2Ra) by HTLV-1-infected In review, we demonstrate IL-15 also contributes cells PBMC. We provide data indicating expression elevated when compared normal donors. Furthermore, overexpression Tax trans-activation promoter induction NF-κB transcription factors. On basis these studies, propose model which infection results both cytokines, growth factors support