Role of the insulin-like growth factor family in cancer development and progression
作者： Herbert Yu , Thomas Rohan
关键词: Growth factor 、 Insulin-like growth factor 、 Cancer prevention 、 Internal medicine 、 Carcinogenesis 、 Cell growth 、 Cancer 、 Cancer cell 、 Endocrinology 、 Cancer research 、 Biology 、 Insulin-like growth factor-binding protein
摘要: The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF-I receptor, which is also involved in cell transformation induced by tumor virus proteins and oncogene products. Six IGF-binding proteins (IGFBPs) can inhibit or enhance the actions of IGFs. These opposing effects are determined by the structures of the binding proteins. The effects of IGFBPs on IGFs are regulated in part by IGFBP proteases. Laboratory studies have …
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