The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue.

摘要: Objective Oxygen transport to parenchymal cells occurs mainly at the microvascular level, and depends on convective red blood cell (RBC) flux, which is proportional in an individual capillary product of hematocrit velocity. This study investigates relative influence these two factors tissue oxygen partial pressure (PO2). Methods A simple analytical model used quantify respective influences hematocrit, RBC velocity flow oxygenation around capillaries. Predicted PO2 levels are compared with a detailed computational model. Results Hematocrit shown have larger than The effect increases distance from arterioles. Good agreement between numerical results obtained discrepancies explained. Significant dependence mass transfer coefficients low demonstrated. Conclusions For given flux capillary, surrounding increasing as consequence decreasing intravascular resistance diffusive RBCs tissue. These contribute understanding effects changes transport, such occur functional hyperemia brain. This article protected by copyright. All rights reserved.