The Development of Protanine-Coated Cellulose Hollow Fibers for Heparin Removal: In Vitro Characterization and in Vivo Testing

摘要: Nearly 20 million extracorporeal blood circulation (ECBC) procedures are conducted each year. They all require heparin anticoagulation to prevent the clotting process which is initiated when comes into contact with device. However, leads a high incidence (830%) of bleeding complications. To avoid such complications, protamine, antidote, generally administered at conclusion an ECBC procedure neutralize anticoagulant activity. Unfortunately intravenous administration protamine often causes serious adverse responses. We suggest approach could control both types The consists placing hollow fiber device containing immobilized (i.e., filter) distal end procedure. filter would remove before returned patient, thereby eliminating any heparin-induced also obviate need and allow for external treatment, protamine-induced In vivo studies involving dogs have shown that capable removing from animal’s circuit. possesses certain anti-thrombogenic activity induces significantly less thrombocytopenic responses compared clinical administration. Other preliminary in data will be presented.