Vitamin D and DBP: the free hormone hypothesis revisited.
作者： Rene F. Chun , Bradford E. Peercy , Eric S. Orwoll , Carrie M. Nielson , John S. Adams
DOI: 10.1016/J.JSBMB.2013.09.012
关键词: Endocrine system 、 Biology 、 Albumin 、 Context (language use) 、 Internal medicine 、 Vitamin D-binding protein 、 Endocrinology 、 Vitamin D and neurology 、 Vitamin 、 Intracrine 、 vitamin D deficiency
摘要: The last five years have witnessed a remarkable renaissance in vitamin D research and complete re-evaluation of its benefits to human health. Two key factors catalyzed these changes. First, it now seems likely that localized, tissue-specific, conversion 25-hydroxyvitamin (25OHD) 1,25-dihydroxyvitamin (1,25(OH)2D) drives many the newly recognized effects on second factor concerns ongoing discussion as what constitutes adequate or optimal serum status, with possibility D-deficiency is common communities across globe. These two concepts appear be directly linked when low concentrations 25OHD compromise intracrine generation 1,25(OH)2D within target tissues. But, this an over-simplification? Pro-hormone lipophilic molecule transported circulation bound primarily binding protein (DBP). While association between DBP pivotal for renal handling endocrine synthesis 1,25(OH)2D, role extra-renal 1,25(OH)2D? We hypothesize impairs delivery D-activating enzyme 1α-hydroxylase some cells. Specifically, unbound, 'free' non-classical actions D. Levels are dependent concentration alternative proteins such albumin, but will also influenced by variations affinity specific metabolites. aim review discuss merits 'free 25OHD' marker particularly context responses This article part Special Issue entitled '16th Vitamin Workshop'.
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