Compositions comprising anti-igf-i receptor antibodies and methods for obtaining said antibodies

作者: Frank J. Calzone , Mei-Mei Tsai , Rajendra V. Deshpande

DOI:

关键词: Nucleic acidPolynucleotideBiologyAntibodyIGF-I ReceptorAntibody fragmentsMolecular biology

摘要: The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the fully human, humanized, chimeric anti­IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments derivatives of such antibodies, polypeptides comprising fragments. Other embodiments provide nucleic acids encoding antibody polypeptides, cells polynucleotides, making using including treating diagnosing subjects having IGF-1R-related disorders conditions.

参考文章(86)
Derek Le Roith, Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. The New England Journal of Medicine. ,vol. 336, pp. 633- 640 ,(1997) , 10.1056/NEJM199702273360907
David S. Salomon, Robert B. Dickson, Hormones and growth factors in development and neoplasia Wiley-Liss. ,(1998)
Elvin A. Kabat, Sequences of proteins of immunological interest National Institutes of Health. ,(1991)
Carl Ivar Branden, John Tooze, Introduction to protein structure ,(1991)
Thomas E. Creighton, Proteins : structures and molecular principles W.H. Freeman. ,(1983)
James P. Merryweather, Lawrence S. Cousens, Patricia A. Tekamp-Olson, Jeffrey R. Shuster, Expression using fused genes providing for protein product ,(1986)
David William Brankow, Shaw-Fen Sylvia Hu, Jean Marie Gudas, Overexpressing cyclin D 1 in a eukaryotic cell line ,(1999)
Rudolf de Wildt, Ian Tomlinson, Laurent Jespers, Nucleic acids, proteins, and screening methods ,(2003)