作者: Frank J. Calzone , Mei-Mei Tsai , Rajendra V. Deshpande
DOI:
关键词: Nucleic acid 、 Polynucleotide 、 Biology 、 Antibody 、 IGF-I Receptor 、 Antibody fragments 、 Molecular biology
摘要: The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the fully human, humanized, chimeric antiIGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments derivatives of such antibodies, polypeptides comprising fragments. Other embodiments provide nucleic acids encoding antibody polypeptides, cells polynucleotides, making using including treating diagnosing subjects having IGF-1R-related disorders conditions.