An albino mouse model of nonalcoholic fatty liver disease induced using high-fat liquid "Lieber-DeCarli" diet: a preliminary investigation.

摘要: Background Experimental diet models have proven to be vital understanding the pathophysiology and management of nonalcoholic fatty liver disease (NAFLD). Lieber-DeCarli high-fat, liquid been used produce NAFLD in rat models. There is, however, currently no information on effects this mouse model. Methods Ten (n = 10) male albino mice (27.7 ± 2.0 g) were divided into 2 groups (n = 5/group). Animals from group 1 fed with standard chow (CD group) those (high-fat or HFD ad libitum for a period 4 weeks. Results Data obtained show insulin resistance significant increase plasma lipid profile. Level cholesterol triglycerides increased significantly (P < .05) compared CD group. Plasma level tumor necrosis factor alpha control. Also, indicators oxidative stress (malondialdehyde protein carbonyls) coupled reduction reduced glutathione (GSH) activity peroxidase Histopathological evaluation sections reveals steatosis ballooned hepatocytes. Conclusions present study suggest that may mouse. This model also features shorter time mice.