Perinatal characteristics and risk of neuroblastoma.

摘要: Neuroblastoma (NB), a tumor of the sympathetic nervous system, is most common infant malignancy. The etiology NB largely unknown. We explored association between birth record variables and subsequent development in population-based case-cohort study Minnesota by linking cancer registries. cases included 155 children born during 1976-2004 who were diagnosed from 28 days through 14 years age. comparison group 8,752 individuals randomly sampled cohort cases. Cox proportional hazards regression was used to calculate hazard ratios (HRs) 95% confidence intervals (CIs). Controlling for year sex, maternal history one fetal loss (HR = 1.7, CI 1.2-2.5), prenatal drug-use (recorded starting 1992) 5.7, 2.3-14) child's small size gestational age 2.1, 1.1-4.0) significantly associated with NB. Age specific analyses indicated that hypertension 3.0, 1.3-7.2) <20 2.6, 1.1-6.1) increased risks only. Our provides evidence few perinatal exposures as recorded records may play role etiology.