THE EFFECTS OF MITOMYCIN C ON THE PROCESS OF REMYELINATION IN THE MAMMALIAN PERIPHERAL NERVOUS SYSTEM
作者： SUSAN M. HALL , N. A. GREGSON
DOI: 10.1111/J.1365-2990.1975.TB00386.X
关键词: Mitomycin C 、 Mitosis 、 Cell biology 、 Schwann cell 、 Endoneurium 、 Immunology 、 Schwann cell proliferation 、 Remyelination 、 Process (anatomy) 、 Peripheral nervous system 、 Medicine
摘要: Schwann cell proliferation is a prominent feature of the normal response peripheral nerve fibre bundle to injurious stimuli. In this report we have attempted analyse: (1) pattern division cells in endoneurium following demyelination induced by lysophosphatidyl choline (LPC), and (2) consequence inhibiting using mitomycin C. The nuclear uptake 3H-thymidine was examined post-LPC nerves with or without pretreatment C means light microscope autoradiography liquid scintillation counting. It found that inhibited follows LPC injection into fibires demyelinated thereby remained unmyelinated surrounded debris-filled axon-associated cells, for at least 1 month after LPC. Remyelination well established control fibres second week injection. nature stimuli which might initiate mitotic activity mature possible function are discussed.
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