Abnormal cortical functional connections in Alzheimer's disease: analysis of inter- and intra-hemispheric EEG coherence.

作者: Zheng-yan Jiang

DOI: 10.1631/JZUS.2005.B0259

关键词: Eeg coherenceAlzheimer's diseaseCoherence (statistics)AudiologyPhotic StimulationAlpha (ethology)ElectroencephalographyCerebral cortexResting eegMedicine

摘要: To investigate inter- and intra-hemispheric electroencephalography (EEG) coherence at rest during photic stimulation of patients with Alzheimer's disease (AD). Thirty-five (12 males, 23 females; 52–64 y) 33 sex- age-matched controls 21 56–65 were recruited in the present study. EEG signals from C3–C4, P3–P4, T5–T6 O1–O2 electrode pairs resulted inter-hemispheric action, C3–P3, C4–P4, P3–O1, P4–O2, C3–O1, C4–O2, T5–O1 T6-O2 action. The influence inter-and on activity eyes closed was examined, using fast Fourier transformation 16 sampled channels. frequencies fixed 5, 10 15 Hz, respectively. general decrease AD more significant than that normal resting EEG, most striking observed alpha-1 (8.0–9.0 Hz) alpha-2 (9.5–12.5 bands. During stimulation, coherences having lower values alpha (9.5–10.5 band those control group. It suggests under stimulated non-stimulated conditions, had impaired functional connections, indicating failure brain activation alpha-related frequency.

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