作者: Sean S. Wang , Olga C. Rodriguez , Ye Tian , Shaozhen Ye , Emanual Petricoin
DOI: 10.1109/GENSIPS.2012.6507717
关键词: Bioinformatics 、 Medulloblastoma 、 In vivo 、 Arsenic trioxide 、 Tumor growth 、 Biological network 、 Childhood brain tumor 、 Gene 、 Systems biology 、 Cancer research 、 Biology
摘要: Medulloblastoma is a highly malignant childhood brain tumor and often characterized by alterations in cell cycle regulatory pathways genes. Using FDA-approved arsenic trioxide (ATO) treated ND2-SmoAl mouse model, we present an integrated imaging systems biology approach to assess responses ATO uncover the complexity of therapeutic molecular biology. Kaplan-Meier survival MRI growth analyses established effectiveness treatment. Differential analysis protein data identified biologically plausible gene markers. dependence network further revealed novel rewiring “hubs” biological networks triggered at level. Functional on statistically significant networked markers confirmed ATO's role as effective anti-proliferative pro-apoptotic drug, vivo.