Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-beta.

作者: Masahiro Iwamoto , Katsuhiko Sato , Kazuhisa Nakashima , Hajime Fuchihata , Fujio Suzuki

DOI: 10.1016/0006-291X(89)92208-0

关键词: Cell cultureInternal medicineChondrocyteCell growthFibroblast growth factorTransforming growth factorEndocrinologyBiologyCartilageCell biologyTransforming growth factor betaCell

摘要: Abstract Fibroblast growth factor (FGF) induces colony formation by chondrocytes in soft agar (Y. Kato et al., J. Cell. Physiol., 1987), and the present study revealed that transforming factor-beta (TGF-beta) does not induce same effect. TGF-beta did, however, increase efficiency of 3- to 4-fold presence a maximal dose FGF. Furthermore, decreased concentrations FGF needed for induction cell 40- 100-fold. These results suggest is involved control cartilage possibly increasing responsiveness

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