Role of the electrostatic interactions on the basic or acidic hydrolysis kinetics of poly-(d,l-lactide) monolayers
作者： Tz. Ivanova , I. Panaiotov , F. Boury , P. Saulnier , J.E. Proust
DOI: 10.1016/S0927-7765(99)00043-0
关键词: Aqueous solution 、 Electrostatics 、 Surface pressure 、 Organic chemistry 、 Polymer 、 Molecule 、 Chemical engineering 、 Monolayer 、 Lactide 、 Chemistry 、 Hydrolysis
摘要: Abstract The hydrolysis kinetics of insoluble poly-( d , l -lactide) monolayers spread on basic or acidic aqueous subphase were followed by measuring simultaneously the decrease in surface area at constant pressure and evolution potential. An approach to analyse role electrostatic interactions during alkaline pH, interpreting potential data was developed. theoretical predictions based idea a random fragmentation polymer molecules leading interfacial accumulation charged products solubilisation small fragments describes well experimental results. reversibility hydrolysis/esterification reaction pH is taken into account.
elsevier.com
sci-hub.se 参考文章(18)
Robert S. Langer, Mark Chasin, Biodegradable polymers as drug delivery systems M. Dekker. ,(1990)
C. C. Chu, The effect of pH on the in vitro degradation of poly(glycolide lactide) copolymer absorbable sutures Journal of Biomedical Materials Research. ,vol. 16, pp. 117- 124 ,(1982) , 10.1002/JBM.820160204
C. A. Helm, L. Laxhuber, M. L�sche, H. M�hwald, Electrostatic interactions in phospholipid membranes I: Influence of monovalent ions Colloid and Polymer Science. ,vol. 264, pp. 46- 55 ,(1986) , 10.1007/BF01410307
F. MacRitchie, P.D.I. Fletcher, Chemistry at interfaces ,(1990)
Catherine Ringard-Lefebvre, Adam Baszkin, Behavior of Poly(D,L-lactic acid) Monolayers at the Air-Water Interface. Effect of Spreading Solvents Langmuir. ,vol. 10, pp. 2376- 2381 ,(1994) , 10.1021/LA00019A057
C. C. Chu, David F. Williams, The effect of gamma irradiation on the enzymatic degradation of polyglycolic acid absorbable sutures Journal of Biomedical Materials Research. ,vol. 17, pp. 1029- 1040 ,(1983) , 10.1002/JBM.820170612
Chung Shih, Chain-end scission in acid catalyzed hydrolysis of poly (d,l-lactide) in solution Journal of Controlled Release. ,vol. 34, pp. 9- 15 ,(1995) , 10.1016/0168-3659(94)00100-9
G SPENLEHAUER, M VERT, J BENOIT, A BODDAERT, In vitro and in vivo degradation of poly(D,L lactide/glycolide) type microspheres made by solvent evaporation method. Biomaterials. ,vol. 10, pp. 557- 563 ,(1989) , 10.1016/0142-9612(89)90063-X
Richard P. Batycky, Justin Hanes, Robert Langer, David A. Edwards, A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres Journal of Pharmaceutical Sciences. ,vol. 86, pp. 1464- 1477 ,(1997) , 10.1021/JS9604117
Robert Verger, Gerard H. de Haas, Enzyme reactions in a membrane model 1: A new technique to study enzyme reactions in monolayers Chemistry and Physics of Lipids. ,vol. 10, pp. 127- 136 ,(1973) , 10.1016/0009-3084(73)90009-1