Hole Traps in DNA

摘要: Sequences of guanines, GG and GGG, are known to be readily oxidized, forming radical cations, i.e., hole traps, on DNA. The trapping probability is less than that GGG. Lewis et al. (J. Am. Chem. Soc. 2000, 122, 12037) have used measurements synthetic hairpins determine the free energy liberated when a goes from cation G+ or They find these energies order thermal at room temperature, in contradiction expectation by many much greater trap depths. We calculated wave function G, GG, GGG surrounded adenines, as experiments, using simple tight-binding model. account for shallow traps found them it necessary difference ionization potentials contiguous guanine adenine smaller about 0.2 eV 0.4 isolated bases. Using this value taking into polaron formation, we functions holes ...