INHIBITION OF REPERFUSION INJURY BY HUMAN THIOREDOXIN (ADULT T-CELL LEUKEMIA-DERIVED) FACTOR IN CANINE LUNG TRANSPLANTATION
作者： Kazuyuki Yagi , Chunjiang Liu , Toru Bando , Hiroyasu Yokomise , Kenji Inui
DOI: 10.1016/S0022-5223(94)70191-1
关键词: Medicine 、 In vivo 、 Lung 、 Lung transplantation 、 Acetylcysteine 、 Pathology 、 Allotransplantation 、 Reperfusion injury 、 Pharmacology 、 Peak inspiratory pressure 、 Pulmonary artery
摘要: Human thioredoxin, which was previously recognized as adult T-cell leukemia-derived factor, has many physiologic activities, one of is a radical scavenger effect. Its ability to reduce reperfusion injury assessed in vivo canine lung transplantation model. In 19 dogs, left allotransplantation performed after 100 minutes warm ischemia. The function the transplanted clamping contralateral pulmonary artery. human thioredoxin group ( n = 6), 30 mg/kg given recipients during reperfusion. N -acetylcysteine 5), N-acetylcysteine 150 mg/kg, known scavenger, same manner. both groups, arterial oxygen tension significantly higher than control 8). group, peak inspiratory pressure lower group. Macroscopic and microscopic examinations showed an almost normal appearance tissues contrast abnormal findings Thus it would appear that protective effect on lungs, does acetylcysteine, its action may be
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