The role of heat shock proteins in inflammatory injury induced by cold stress in chicken hearts
作者： Shi-Wen Xu , Fu-Qing Zhao , Zi-Wei Zhang , Chao Wang , Bo Zhang
DOI: 10.1007/S12192-013-0429-8
关键词: Malondialdehyde 、 Oxidative phosphorylation 、 Tumor necrosis factor alpha 、 Heat shock protein 、 Glutathione peroxidase 、 Hsp90 、 Superoxide dismutase 、 Endocrinology 、 Oxidative stress 、 Immunology 、 Medicine 、 Internal medicine
摘要: The aim of this study was to investigate the effects cold stress on expression levels heat shock proteins (Hsps90, 70, 60, 40, and 27) inflammatory factors (iNOS, COX-2, NF-κB, TNF-α, PTGEs) oxidative indexes in hearts chickens. Two hundred forty 15-day-old male chickens were randomly divided into 12 groups kept at temperature 12 ± 1 °C for acute chronic stress. There one control group five treatment stress, three groups, After malondialdehyde level increased chicken heart; activity superoxide dismutase glutathione peroxidase heart first then decreased. mRNA relative groups. histopathological analysis showed that tissues seriously injured group. Additionally, Hsps (70, significantly (P < 0.05) corresponding Meanwhile, protein Hsp90 decreased group, a gradually decreasing tendency. These results suggested can be influenced by commonly played an important role protection after
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