Oropharyngeal cancer: current understanding and management.

摘要: Purpose of review The goals this article are: to briefly oropharyngeal anatomy; provide a the epidemiology cancer in Western Hemisphere; literature on association human papilloma virus with cancer; recent evolving diagnostic techniques for and summarize accepted management strategies by subsite. Recent findings incidence may be increasing among younger age groups Hemisphere, related an increased papillomavirus 16. implications viral regard outcomes remain under investigation. Screening toluidine blue, autofluorescence, or both useful adjuncts physical examination panendoscopy assessing potentially invasive dysplastic lesions oropharynx. These study. MRI PET scan are proving local extension, regional metastases, recurrences squamous cell carcinoma (SCC) oropharynx selected cases. However, serial computed tomography scanning remains imaging modality choice United States. Early SCCs (T1–2), general, managed effectively either surgery primary irradiation, though, technique, clinicians must have plan neck. Advanced (T3–4, nodally aggressive, both) require multimodal approaches consisting along adjuvant irradiation concurrent chemoradiation salvage (as necessary). Summary Management SCC is period transition because changes our understanding oncogenic process; techniques; combinations therapies, surgical nonsurgical. For time being, we propose using subsite disease stage guide therapeutic decision-making.