Low-molecular-weight heparin (LMWH)-loaded large porous PEG-PLGA particles for the treatment of asthma.
作者： Brijeshkumar Patel , Nilesh Gupta , Fakhrul Ahsan
关键词: Low molecular weight heparin 、 Inflammation 、 Ovalbumin 、 Immunology 、 Anti-asthmatic Agent 、 Anti-inflammatory 、 Drug carrier 、 Pharmacology 、 Chemistry 、 Heparin 、 Asthma
摘要: Abstract Background: Heparin-like compounds interrupt leukocyte adhesion and migration, prevent release of chemical mediators during the process inflammation. However, little is known whether anti-inflammatory property smaller heparin fragments, low-molecular-weight (LMWH), plays any role in airway In this study, we sought to evaluate efficacy LMWH-loaded large porous polyethylene glycol–poly(D,L-lactide-co-glycolide) (PEG-PLGA) particulate formulations alleviating cellular biochemical changes associated with asthma. Methods: To study pharmacological LMWH for treatment asthma, have used a previously optimized polymeric formulation LMWH. The anti-asthmatic was studied an ovalbumin-sensitized rat model influence on asthmatic lungs assessed by measuring total protein content number inflammatory cells bronchoalveolar ...
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