The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen (AIDS clinical trials group protocol 850).

摘要: Antiretroviral therapy may lead to decreased shedding of human immunodeficiency virus type 1 (HIV-1) in genital secretions. Thirty men, 19 receiving amprenavir and 11 amprenavir, zidovudine, lamivudine, donated blood semen while undergoing treatment, evaluate the effects these medications on HIV-1 semen. Before therapy, 4 men had RNA levels seminal plasma >6.0 log10 (1 million) copies/mL, markedly higher than plasma. Most (77%) below limit quantification during therapy. Amprenavir alone suppressed <400 copies/mL majority patients, first direct demonstration antiretroviral a protease inhibitor male tract. However, 8 (27%) measurable at their last study visit, with increasing levels. Persistent replication HIV tract have implications for selection resistant sexual transmission HIV-1.