Effects of the progestin antagonist RU 486 on T-47D breast cancer cell cycle kinetics and cell cycle regulatory genes.

摘要: Possible mechanisms by which the progestin antagonist RU 486 inhibits cell growth were investigated comparing effects of antiprogestin with those and antiestrogen. Exposure T-47D breast cancer cells to caused a decline in proportion S phase, indicative block cycle progression G1 phase. This was accompanied marked decrease c-myc expression but no change cyclin D1 expression. The kinetic data suggest that inhibition proliferation stimulation are mediated opposing on same mechanism. Both estrogen antagonists appear act at similar part phase there clear differences their expression, suggesting these compounds inhibit distinct.