Rational Dosing of Chemotherapy in Patients with Kidney Failure

摘要: The prevalence of chronic kidney disease (CKD) and end-stage Kidney (ESKD) is continuing to rise. Meticulous attention drug dosing paramount in patients with reduced or absent function. Cancer poses unique challenges CKD, particularly as relates chemotherapy selection dosing. In this chapter, we discuss different methods estimating function order provide rational When selecting chemotherapeutic agents CKD ESKD, one should first consider, whenever possible, choosing that are mostly eliminated via the hepatic route, thereby “bypassing” issues surrounding impaired renal excretion. However, if a agent chosen primarily kidney, it imperative glomerular filtration rate (GFR) be estimated so adjust dose appropriately. Careful monitoring levels when available certain prophylactic measures, for example, adequate hydration, can help reduce potential toxicity limit untoward effects agents. Finally, has cognizant interactions, those involving inherent nephrotoxic properties.