The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma.

摘要: Objectives Tumor-infiltrating lymphocytes (TILs) play a crucial role in anti-tumor immunity. Basic studies have found that stimulator of interferon genes (STING), activated by sensing DNA damage, plays recruiting and activating TILs tumors. However, the correlation between base excision repair (BER) pathway, STING pathway TILS their effect on prognosis upper urinary tract urothelial carcinoma (UTUC) are still unclear. The aim this study was to investigate prognostic those proteins expression for disease-free survival (DFS) overall (OS) explore these makers. Methods We evaluated immunohistochemical BER (APE1, NTH1, OGG1, XRCC1, polβ), (STING, IRF3), (CD4, CD8, CD20) PD-L1, PD-L2 88 UTUC patients determine predictive significance DFS, OS them. Results regulatory factor3 (IRF3) (HR: 0.451, 95% CI 0.243-0.837, p=0.024) CD8 0.522, 0.295-0.926, p=0.014) independent factors APE1 1.932, 1.005-3.714, P=0.048), polβ 2.620, 1.373-5.000, P=0.003), 0.323, 0.151-0.693, P=0.004) were OS. A model consisting stage, grade, lymphovascular invasion APE1, polβ, IRF3, CD4, predicts 3-year Furthermore, damage protein is associated with CD8+ T cells TME. Conclusion IRF3 predictors prognosis. also provided clinical evidence repair-activated can induce recruitment activation TILs, which consistent preclinical models.