Multidimensional view of amyloid fibril nucleation in atomistic detail.
作者： Fahimeh Baftizadeh , Xevi Biarnes , Fabio Pietrucci , Fabio Affinito , Alessandro Laio
DOI: 10.1021/JA210826A
关键词: Antiparallel (biochemistry) 、 Crystallography 、 Chemistry 、 Metadynamics 、 Protein aggregation 、 Amyloid fibril 、 Classical nucleation theory 、 Nucleation 、 Molecular dynamics 、 Nucleus 、 Chemical physics
摘要: … This allowed characterizing in detail a possible nucleation pathway for the formation of amyloid fibrils: first the system forms a relatively large ordered nucleus of antiparallel β-sheets, …
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