Photoprotective actions of vitamin E in mouse skin: Prevention of UVB-induced DNA photodamage
作者： Maralee McVean
DOI:
关键词: In vivo 、 Biology 、 Skin cancer 、 Vitamin E 、 In vitro 、 Mouse skin 、 DNA 、 Pyrimidine dimer 、 Pharmacology 、 Carcinogenesis
摘要: 13 CHAPTER 1 15 Introduction Vitamin E 17 Health effects of vitamin 28 Skin cancer 31 The role pyrimidine dimers in UV induced skin carcinogenesis 43 Use sunscreens the prevention damage 59 tocopherols 65 Rationale 73 Hypothesis and Specific Aims 74 2 TOPICALLY APPLIED A-TOCOPHEROL PREVENTS UVB INDUCED DNA PHOTODAMAGE IN THE MOUSE EPIDERMIS 75 Experimental Procedures 78 Results 85 Discussion 102 TABLE OF CONTENTS Continued 3 UNIQUE VIVO EFFECTIVENESS A-TOCOPHEROLS AS A PHOTOPROTECTANT 107 109 114 126 4 CELLULAR UPTAKE. DISTRIBUTION AND PHOTOPROTECTIVE ACTIONS VITAMIN COMPOUNDS VITRO
openrepository.com参考文章(291)
Michel Clément, Lan Dinh, Jean-Marie Bourre, Uptake of dietary RRR-α- and RRR-γ-tocopherol by nervous tissues, liver and muscle in vitamin-E-deficient rats Biochimica et Biophysica Acta. ,vol. 1256, pp. 175- 180 ,(1995) , 10.1016/0005-2760(95)00019-9
Tsukasa Matsunaga, David Mu, Chi-Hyun Park, Joyce T. Reardon, Aziz Sancar, Human DNA Repair Excision Nuclease Journal of Biological Chemistry. ,vol. 270, pp. 20862- 20869 ,(1995) , 10.1074/JBC.270.35.20862
E. Straface, M. Teresa Santini, G. Donelli, P. Ulderico Giacomoni, W. Malorni, Vitamin E prevents UVB-induced cell blebbing and cell death in A431 epidermoid cells. International Journal of Radiation Biology. ,vol. 68, pp. 579- 587 ,(1995) , 10.1080/09553009514551571
Karla Werninghaus, Mohsen Meydani, Jag Bhawan, Randall Margolis, Jeffrey B Blumberg, Barbara A Gilchrest, Evaluation of the Photoprotective Effect of Oral Vitamin E Supplementation Archives of Dermatology. ,vol. 130, pp. 1257- 1261 ,(1994) , 10.1001/ARCHDERM.1994.01690100041005
Ming-Kuei Shih, Miao-Lin Hu, UVA-potentiated damage to calf thymus DNA by Fenton reaction system and protection by para-aminobenzoic acid. Photochemistry and Photobiology. ,vol. 63, pp. 286- 291 ,(1996) , 10.1111/J.1751-1097.1996.TB03027.X
Gary L. Grove, Kays H. Kaidbey, Sunscreens Prevent Sunburn Cell Formation in Human Skin Journal of Investigative Dermatology. ,vol. 75, pp. 363- 364 ,(1980) , 10.1111/1523-1747.EP12531216
Sang-Tae Kim, Aziz Sancar, PHOTOCHEMISTRY, PHOTOPHYSICS, AND MECHANISM OF PYRIMIDINE DIMER REPAIR BY DNA PHOTOLYASE Photochemistry and Photobiology. ,vol. 57, pp. 895- 904 ,(1993) , 10.1111/J.1751-1097.1993.TB09232.X
Maureen Munn, W. Dean Rupp, David P. Lane, Richard D. Wood, Dawn Coverley, Mark K. Kenny, Requirement for the replication protein SSB in human DMA excision repair Nature. ,vol. 349, pp. 538- 541 ,(1991) , 10.1038/349538A0
David L. Mitchell, The relative cytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells. Photochemistry and Photobiology. ,vol. 48, pp. 51- 57 ,(2008) , 10.1111/J.1751-1097.1988.TB02785.X
H Kappus, Tolerance and safety of vitamin E: A toxicological position report☆ Free Radical Biology and Medicine. ,vol. 13, pp. 55- 74 ,(1992) , 10.1016/0891-5849(92)90166-E