Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells
作者： Zar Chi Soe , Jun Bum Kwon , Raj Kumar Thapa , Wenquan Ou , Hanh Thuy Nguyen
DOI: 10.3390/PHARMACEUTICS11020063
关键词: Doxorubicin 、 Cancer cell 、 Apoptosis 、 In vivo 、 Transferrin 、 Cell cycle 、 Cancer research 、 Chemistry 、 Cell culture 、 Cytotoxicity
摘要: In this study, a transferrin (Tf)-conjugated polymeric nanoparticle was developed for the targeted delivery of chemotherapeutic agent doxorubicin (Dox) in order to overcome multi-drug resistance cancer treatment. Our objective improve Dox producing significant antitumor efficacy Dox-resistant (R) breast cell lines with minimum toxicity healthy cells. The results our experiments revealed that successfully loaded inside composed poloxamer 407 (F127) and 123 (P123) (Dox/F127&P123-Tf), which produced nanosized particles (~90 nm) low polydispersity index (~0.23). accelerated controlled release profiles from nanoparticles were characterized acidic physiological pH Dox/F127&P123-Tf enhanced cytotoxicity OVCAR-3, MDA-MB-231, MDA-MB-231(R) through induction cellular apoptosis. Moreover, inhibited migration altered cycle patterns different vivo study tumor-bearing mice demonstrated tumor site when coated targeting moiety. Therefore, has been tailored, using principles nanotherapeutics, drug-resistant chemotherapy.
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