Resistance-Associated Signatures in Breast Cancer

摘要: A major obstacle in the treatment of breast cancer is lack adequate methods for predicting patient response to a particular chemotherapy regime. To date, single tumour markers have provided limited success. DNA array technologies identifying thousands genes simultaneously can help solve this problem. We investigated cell lines sensitive and resistant topoisomerase inhibitors doxorubicin mitoxantrone. These drugs are used several different protocols. identified top best associated with resistance against each cytostatic agent. applied our gene expression signatures set pre-characterised patients receiving monotherapy. The classified as exhibited longer survival than ones. In summary, study we successfully transferred experimental results clinical problem, managed perform predictive test selected monotherapy protocol. However, many studies been performed using microarrays, producing list same classification It likely that future diagnostic tools will include laboratories, focus on validated technological platforms use large cohorts patients.