Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men
作者： Matthew Cocks , Christopher S. Shaw , Sam O. Shepherd , James P. Fisher , Aaron M. Ranasinghe
DOI: 10.1111/MICC.12155
关键词: Arterial stiffness 、 Blood pressure 、 Microvascular Density 、 Skeletal muscle 、 Endurance training 、 Biology 、 Enos 、 Microcirculation 、 Internal medicine 、 Endocrinology 、 Basal (phylogenetics)
摘要: OBJECTIVE: The effects of RT on muscle mass, strength, and insulin sensitivity are well established, but the underlying mechanisms only partially understood. main aim this study was to investigate whether induces changes in endothelial enzymes microvasculature, which would increase NO bioavailability could contribute improved sensitivity. METHODS: Eight previously sedentary males (age 20 ± 0.4 years, BMI 24.5 ± 0.9 kg/m(2) ) completed six weeks 3x/week. Muscle biopsies were taken from m. vastus lateralis microvascular density; endothelial-specific eNOS content, Ser(1177) phosphorylation, NOX2 content assessed pre- post-RT using quantitative immunofluorescence microscopy. Whole-body (measured as Matsuda Index), Kf (functional measure total available surface area), arterial stiffness (AIx, central, pPWV) also measured. RESULTS: Measures density, , basal did not change pre-RT post-RT. increased (p < 0.05) reduced resting blood pressure AIx (p < 0.05), central or pPWV. CONCLUSIONS: any structure function.
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