Dopamine D(2) receptor activation modulates perceived odor intensity.
作者： Catherine J. Wei , Christiane Linster , Thomas A. Cleland
DOI: 10.1037/0735-7044.120.2.393
关键词: Stimulus (physiology) 、 Olfactory system 、 Odor 、 Agonist 、 Chemistry 、 Quinpirole 、 Neuroscience 、 Olfaction 、 Spiperone 、 Dopamine
摘要: Dopaminergic modulation affects odor detection thresholds and olfactory discrimination capabilities in rats. The authors show that dopamine D 2 receptor a manner similar to the of stimulus intensity. Performance simultaneous task was systematically altered by manipulations both odorant concentration activation (agonist quinpirole, 0.025-0.5 mg/kg; antagonist spiperone, 0.5 mg/kg). Rats' performance improved at higher concentrations. Blockade receptors equivalent increasing log units, whereas reduced dose-dependent manner. Bulbar release may serve gain control function system, optimizing its sensitivity changes chemosensory environment.
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