The neutrophil-to-lymphocyte ratio is inversely associated with adductor pollicis muscle thickness in older patients with gastrointestinal tract cancer.

作者: Lara G Mainardi , Renata C Fernandes , Gustavo D Pimentel , None

DOI: 10.1016/J.NUT.2020.110887

关键词: CancerTumor stageSystemic inflammationOlder patientsGastrointestinal tractBody mass indexAdductor pollicis muscleGastroenterologyNeutrophil to lymphocyte ratioInternal medicineMedicine

摘要: Abstract Objectives The neutrophil-to-lymphocyte ratio (NLR) is considered a systemic inflammatory marker and has been associated with poor prognosis in various cancer types. aim of this study was to assess whether lower NLR values are higher adductor pollicis muscle thickness (APMT) patients gastrointestinal tract cancer. Methods A cross-sectional assessed 99 digestive system cancers. Tumor stage analyzed by physician. Body mass index (BMI; kg/m2) calculated using the body weight (kg) divided height (m) squared; APMT (mm) skinfold caliper; handgrip strength dynamometer; calf circumference (cm) an inelastic tape; gait speed distance four meters walk (m/s); habitual food intake 24-h recall. Systemic inflammation measured NLR. ≥5.0 were high Results ≥ 5.0 group presented compared 0.05). Additionally, than Conclusions In cancer, negatively APMT.

参考文章(22)
Kenneth C Fearon, Anne C Voss, Deborah S Hustead, Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis The American Journal of Clinical Nutrition. ,vol. 83, pp. 1345- 1350 ,(2006) , 10.1093/AJCN/83.6.1345
Arnoud J Templeton, Mairéad G McNamara, Boštjan Šeruga, Francisco E Vera-Badillo, Priya Aneja, Alberto Ocaña, Raya Leibowitz-Amit, Guru Sonpavde, Jennifer J Knox, Ben Tran, Ian F Tannock, Eitan Amir, None, Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis Journal of the National Cancer Institute. ,vol. 106, ,(2014) , 10.1093/JNCI/DJU124
William J Durham, Edgar Lichar Dillon, Melinda Sheffield-Moore, Inflammatory burden and amino acid metabolism in cancer cachexia Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 12, pp. 72- 77 ,(2009) , 10.1097/MCO.0B013E32831CEF61
Kenneth C.H. Fearon, David J. Glass, Denis C. Guttridge, Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metabolism. ,vol. 16, pp. 153- 166 ,(2012) , 10.1016/J.CMET.2012.06.011
Matthew J. Delano, Lyle L. Moldawer, The Origins of Cachexia in Acute and Chronic Inflammatory Diseases Nutrition in Clinical Practice. ,vol. 21, pp. 68- 81 ,(2006) , 10.1177/011542650602100168
Rosalia Bragagnolo, Fernanda Stephan Caporossi, Diana Borges Dock-Nascimento, José eduardo de Aguilar-Nascimento, [Adductor pollicis muscle thickness: a fast and reliable method for nutritional assessment in surgical patients]. Revista do Colégio Brasileiro de Cirurgiões. ,vol. 36, pp. 371- 376 ,(2009) , 10.1590/S0100-69912009000500003
ZY Chen, K Raghav, CH Lieu, ZQ Jiang, Cathy Eng, JN Vauthey, GJ Chang, W Qiao, Jeffrey Morris, D Hong, P Hoff, H Tran, DG Menter, J Heymach, M Overman, S Kopetz, None, Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer British Journal of Cancer. ,vol. 112, pp. 1088- 1097 ,(2015) , 10.1038/BJC.2015.61
T Kantola, K Klintrup, J P Väyrynen, J Vornanen, R Bloigu, T Karhu, K-H Herzig, J Näpänkangas, J Mäkelä, T J Karttunen, A Tuomisto, M J Mäkinen, Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma British Journal of Cancer. ,vol. 107, pp. 1729- 1736 ,(2012) , 10.1038/BJC.2012.456
David J Glass, Signaling pathways perturbing muscle mass. Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 13, pp. 225- 229 ,(2010) , 10.1097/MCO.0B013E32833862DF
Graeme J.K. Guthrie, Kellie A. Charles, Campbell S.D. Roxburgh, Paul G. Horgan, Donald C. McMillan, Stephen J. Clarke, The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer Critical Reviews in Oncology Hematology. ,vol. 88, pp. 218- 230 ,(2013) , 10.1016/J.CRITREVONC.2013.03.010