Effect of prolonged individual caging on toxicity parameters in rats
作者： G.S. Wiberg , H.C. Grice
DOI: 10.1016/S0015-6264(65)80207-3
关键词: Anesthesia 、 Endocrinology 、 Central nervous system 、 Loss of righting reflex 、 Internal medicine 、 Median lethal dose 、 Chloral hydrate 、 Adrenergic 、 Toxicity 、 Chemistry 、 Sodium 、 Age and sex 、 Toxicology
摘要: Abstract Prolonged individual caging of rats, as is sometimes employed in long-term toxicity tests, was accompanied by several changes parameters toxicity. In comparison to community-housed animals same age and sex, acute LD 50 s might be increased or decreased. Pentobarbitone chloral hydrate sleeping times were reduced the induction period for loss righting reflex with sodium amytal prolonged. The extent these dependent upon length isolation, strain. A possible explanation altered toxic responses that adrenergic ergotropic component central nervous system had undergone an increase activity isolated animals.
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sci-hub.se 参考文章(9)
Frank Wilcoxon, Individual Comparisons by Ranking Methods Springer Series in Statistics. ,vol. 1, pp. 196- 202 ,(1992) , 10.1007/978-1-4612-4380-9_16
Curt P. Richter, Sally H. Dieke, ACUTE TOXICITY OF THIOUREA TO RATS IN RELATION TO AGE, DIET, STRAIN AND SPECIES VARIATION Journal of Pharmacology and Experimental Therapeutics. ,vol. 83, pp. 195- 202 ,(1945)
A.M. Hatch, G.S. Wiberg, Z. Zawidzka, M. Cann, J.M. Airth, H.C. Grice, Isolation syndrome in the rat Toxicology and Applied Pharmacology. ,vol. 7, pp. 737- 745 ,(1965) , 10.1016/0041-008X(65)90132-8
A. Hatch, G. S. Wiberg, T. Balazs, H. C. Grice, LONG-TERM ISOLATION STRESS IN RATS. Science. ,vol. 142, pp. 507- 507 ,(1963) , 10.1126/SCIENCE.142.3591.507
Gertrude P. Quinn, Julius Axelrod, Bernard B. Brodie, Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline Biochemical Pharmacology. ,vol. 1, pp. 152- 159 ,(1958) , 10.1016/0006-2952(58)90024-8
T. Balazs, J. B. Murphy, H. C. Grice, THE INFLUENCE OF ENVIRONMENTAL CHANGES ON THE CARDIOTOXICITY OF ISOPRENALINE IN RATS Journal of Pharmacy and Pharmacology. ,vol. 14, pp. 750- 755 ,(1962) , 10.1111/J.2042-7158.1962.TB11171.X
F Wilcoxon, J T Litchfield, A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS Journal of Pharmacology and Experimental Therapeutics. ,vol. 96, pp. 99- 113 ,(1949)
Harald G. O. Holck, Lucille M. Mills, Edwin L. Smith, Munîr A. Kanân, STUDIES UPON THE SEX-DIFFERENCE IN RATS IN TOLERANCE TO CERTAIN BARBITURATES AND TO NICOTINE Journal of Pharmacology and Experimental Therapeutics. ,vol. 60, pp. 323- 346 ,(1937)
Billy D. Rupe, William F. Bousquet, Tom S. Miya, ENDOCRINE MODIFICATION OF DRUG RESPONSES IN THE RAT Journal of Pharmacology and Experimental Therapeutics. ,vol. 147, pp. 376- 379 ,(1965)