Adverse Clinical Consequences of Hyperglycemia from Total Parenteral Nutrition Exposure during Hematopoietic Stem Cell Transplantation

摘要: Abstract Immunocompromised hematopoietic stem cell transplant (HSCT) recipients frequently receive total parenteral nutrition (TPN), a dextrose-based solution that may exacerbate the infectious risks associated with hyperglycemia. This study assessed incidence of hyperglycemia (glucose level ≥110 mg/dL) and its effect on clinical outcomes in TPN versus non-TPN who received HSCTs. A retrospective cohort 357 adults were admitted for initial autologous or allogeneic transplantation at 2 university-affiliated centers was examined. To discern temporality outcomes, "before" "after" comparisons made by using actual infusion times patients timeframes based mean hospital days before ("before") during ("after") patients. Patients demonstrated similar demographic characteristics when analyzed institution, feeding, donor-type strata, 57% TPN. After attempts to equilibrate disease acuity employed, proportion hyperglycemic equivalent but significantly greater after exposed unexposed (87.5% 8.3%, respectively; P