Changing Paradigms in the Treatment of Malignant Pheochromocytoma

摘要: BACKGROUND Pheochromocytomas and paragangliomas are intra- extra-adrenal neoplasms that rarely malignant. The treatment of those malignant has remained a challenge because little was known about the molecular pathways involved in its transformation. Recently, however, genetic changes pheochromocytoma have come to be understood. METHODS authors review recent literature changing options for pheochromocytomas paragangliomas. RESULTS Traditional treatments remain unsuccessful. With advances made genomics proteomics, novel carcinogenesis becoming targets new strategies show promising results. CONCLUSIONS Although several studies clinical trials great promise improving paragangliomas, hope is future collaborative efforts will allow prospective using an evidenced-based approach.