Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

摘要: Abstract Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It accompanied by other related polyphenols, including magnolol, with which it shares certain biologic properties. Recently, honokiol has been found to have antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, without appreciable toxicity. These findings increased interest bringing clinic as novel chemotherapeutic agent. In addition, mechanistic studies tried find mechanism(s) of action honokiol, for two major reasons. First, knowledge mechanisms may assist development synthetic analogues. Second, actions lead rational combinations conventional chemotherapy or radiation enhanced response systemic cancers. this review, we describe that action. blocks signaling tumors defective p53 function activated ras direc...