Recent developments in biased agonism.
作者： James W Wisler , Kunhong Xiao , Alex RB Thomsen , Robert J Lefkowitz
DOI: 10.1016/J.CEB.2013.10.008
关键词: Biology 、 Agonist 、 Neuroscience 、 Pharmacology 、 G protein-coupled receptor 、 Signal transduction 、 Functional selectivity 、 Biophysical Phenomena
摘要: The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change …
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