Human Leukocyte Antigen Profiles of Latin American Populations: Differential Admixture and Its Potential Impact on Hematopoietic Stem Cell Transplantation
作者： Esteban Arrieta-Bolaños , J. Alejandro Madrigal , Bronwen E. Shaw
DOI: 10.1155/2012/136087
关键词: Graft-versus-host disease 、 Population 、 Disease 、 Latin Americans 、 Evolutionary biology 、 Population genetics 、 Allele 、 Hematopoietic stem cell transplantation 、 Medicine 、 Human leukocyte antigen
摘要: The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic including human leukocyte antigen (HLA) non-HLA variants are believed to influence the risk potentially fatal complications after transplant. Moreover, ethnicity has been proposed as a factor modifying graft-versus-host disease. populations Latin America complex array different admixture processes with varying degrees ancestral population proportions came in migration waves. This complexity makes study risks this region complicated unless extent variation thoroughly characterized. In we compared HLA-A HLA-B allele group profiles for 31 American 61 from Iberia, Italy, Sub-Saharan Africa, America. Results genetics comparisons show wide HLA correlate proportions. Populations seem be organized at least three groups (1) strong Amerindian admixture, (2) Caucasian component, (3) Caucasian-African gradient. These results imply assessment HSCT adapted subgroups rather than pan-Hispanic/Latino analysis.
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