Osteonecrosis and intravascular coagulation revisited

摘要: The primary pathophysiologic feature of advanced osteonecrosis is a zone necrotic bone containing trabeculae with dead osteocytes associated marrow necrosis and fibrosis [1]. This pathognomonic led to the use expression “avascular necrosis,” although international society for study circulation its disorders, ARCO International (Association Internationale pour la Recherche sur Circulation Osseuse), recommends using term “osteonecrosis.” There are several theories regarding pathogenesis [ON], as discussed in outstanding review articles [2–6]. These can be categorized (1) extraosseous, (2) intraosseous, or (3) direct cellular. many other well, such intravascular extravascular pathologies. John Paul Jones, Jr., suggested that multiple etiologies may lead final common pathway coagulation. He hypothesized coagulation an “intermediary mechanism” development ON [7]. evidence plays integral role both indirect will focus this chapter.