Characterization and Bioavailability of Vitamin C Nanoliposomes Prepared by Film Evaporation-Dynamic High Pressure Microfluidization
作者： Shuibing Yang , Wei Liu , Chengmei Liu , Weilin Liu , Guihong Tong
DOI: 10.1080/01932691.2011.629511
关键词: Liposome 、 Chemistry 、 Antioxidant 、 Bioavailability 、 Vitamin C 、 Particle size 、 DPPH 、 Evaporation 、 Permeation 、 Chromatography
摘要: Vitamin C nanoliposomes were prepared by combining a conventional method (film evaporation) with dynamic high pressure microfluidization. Their physicochemical characterizations (antioxidant activity, particle size, entrapment efficiency, morphology, in vitro drug release, and storage stability) skin permeation behavior investigated. The results showed that vitamin nanoliposomes, having equivalent DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical scavenging capacity of pure solution without loss their biological exhibited better stability at 37°C for 24 hours 4°C 60 days, more excellent sustained release as well higher penetration rate than liposomes.
sci-hub.se 参考文章(36)
Efficient Transdermal Penetration and Improved Stability of L-Ascorbic Acid Encapsulated in an Inorganic Nanocapsule Bulletin of The Korean Chemical Society. ,vol. 24, pp. 499- 503 ,(2003) , 10.5012/BKCS.2003.24.4.499
Eva S. Wintergerst, Silvia Maggini, Dietrich H. Hornig, Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions Annals of Nutrition and Metabolism. ,vol. 50, pp. 85- 94 ,(2006) , 10.1159/000090495
Branka Rozman, Alenka Zvonar, Francoise Falson, Mirjana Gasperlin, Temperature-Sensitive Microemulsion Gel: An Effective Topical Delivery System for Simultaneous Delivery of Vitamins C and E AAPS PharmSciTech. ,vol. 10, pp. 54- 61 ,(2009) , 10.1208/S12249-008-9172-3
Ramon Barnadas-Rodrı́guez, Manuel Sabés, Factors involved in the production of liposomes with a high-pressure homogenizer. International Journal of Pharmaceutics. ,vol. 213, pp. 175- 186 ,(2001) , 10.1016/S0378-5173(00)00661-X
Minghui Fan, Shiying Xu, Shuqin Xia, Xiaoming Zhang, Preparation of salidroside nano-liposomes by ethanol injection method and in vitro release study European Food Research and Technology. ,vol. 227, pp. 167- 174 ,(2008) , 10.1007/S00217-007-0706-9
Lei Zhang, Sheldon Lerner, William V Rustrum, Günter A Hofmann, Electroporation-mediated topical delivery of vitamin C for cosmetic applications. Bioelectrochemistry and Bioenergetics. ,vol. 48, pp. 453- 461 ,(1999) , 10.1016/S0302-4598(99)00026-4
Nan Liu, Hyun-Jin Park, Factors effect on the loading efficiency of Vitamin C loaded chitosan-coated nanoliposomes. Colloids and Surfaces B: Biointerfaces. ,vol. 76, pp. 16- 19 ,(2010) , 10.1016/J.COLSURFB.2009.09.041
S. Zheng, H. Alkan-Onyuksel, R.L. Beissinger, D.T. Wasan, Liposome microencapsulations without using any organic solvent Journal of Dispersion Science and Technology. ,vol. 20, pp. 1189- 1203 ,(1999) , 10.1080/01932699908943844
Wei Liu, Wei-Lin Liu, Cheng-Mei Liu, Jian-Hua Liu, Shui-Bing Yang, Hui-Juan Zheng, Han-Wu Lei, Roger Ruan, Ti Li, Zong-Cai Tu, Xin-Yong Song, Medium-chain fatty acid nanoliposomes for easy energy supply Nutrition. ,vol. 27, pp. 700- 706 ,(2011) , 10.1016/J.NUT.2010.06.010
M. Reza Mozafari, Kianoush Khosravi-Darani, G. Gokce Borazan, Jian Cui, Abbas Pardakhty, Seyhun Yurdugul, Encapsulation of Food Ingredients Using Nanoliposome Technology International Journal of Food Properties. ,vol. 11, pp. 833- 844 ,(2008) , 10.1080/10942910701648115