1-Aminooxy-3-aminopropane, a new and potent inhibitor of polyamine biosynthesis that inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase

作者: R.M. Khomutov , T. Hyvönen , E. Karvonen , L. Kauppinen , T. Paalanen

DOI: 10.1016/0006-291X(85)90458-9

关键词: SpermidinePutrescineOrnithine decarboxylase antizymeBiochemistryAdenosylmethionine decarboxylaseMolecular biologyTyrosine aminotransferaseSpermine synthaseSpermidine synthaseChemistryOrnithine decarboxylase

摘要: Aminooxy-3-aminopropane was shown to be a potent competitive inhibitor (K i = 3.2 nM) of homogenous mouse kidney ornithine decarboxylase, a potent irreversible inhibitor (K i = 50 …

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