Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
作者： James A. McCubrey , Linda S. Steelman , Steven L. Abrams , John T. Lee , Fumin Chang
DOI: 10.1016/J.ADVENZREG.2006.01.004
关键词: MAPK/ERK pathway 、 Growth factor receptor 、 Protein phosphatase 2 、 Carcinogenesis 、 Signal transduction 、 Biology 、 Protein kinase B 、 PTEN 、 Cancer research 、 PI3K/AKT/mTOR pathway
摘要: The Ras/Raf/MEK/ERK and PI3K/PTEN/AKT signaling cascades play critical roles in the transmission of signals from growth factor receptors to regulate gene expression and prevent …
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