Transient brain activity disentangles fMRI resting-state dynamics in terms of spatially and temporally overlapping networks

摘要: Dynamics of resting-state functional magnetic resonance imaging (fMRI) provide a new window onto the organizational principles brain function. Using state-of-the-art signal processing techniques, we extract innovation-driven co-activation patterns (iCAPs) from fMRI. The iCAPs’ maps are spatially overlapping and their sustained-activity signals temporally overlapping. Decomposing fMRI using iCAPs reveals rich spatiotemporal structure components that dynamically assemble known networks. temporal overlap between is substantial; typically, three to four occur simultaneously in combinations consistent with behaviour profiles. In contrast conventional connectivity analysis, which suggests negative correlation fluctuations default-mode network (DMN) task-positive networks, instead find evidence for two DMN-related consisting posterior cingulate cortex differentially interact attention network. These findings demonstrate how resting state can be functionally decomposed into building blocks iCAPs.