Discriminative stimulus effects of ethanol: lack of antagonism with N-methyl-D-aspartate and D-cycloserine.
作者： Przemyslaw Bienkowski , Roman Stefanski , Wojciech Kostowski
DOI: 10.1016/S0741-8329(96)00181-4
关键词: Glutamate binding 、 Excitatory Amino Acid Agonist 、 Agonist 、 Chemistry 、 D-cycloserine 、 Stimulus control 、 Glycine receptor 、 NMDA receptor 、 Partial agonist 、 Pharmacology
摘要: Several drug discrimination studies reported that both competitive and uncompetitive NMDA receptor antagonists substituted for ethanol stimulus in rats. In the present study we examined if compounds act as agonists at complex, D-cycloserine (a partial agonist glycine positive modulatory site) N-methyl-D-aspartate (an glutamate binding site), could antagonize discriminative effects of ethanol. Rats were trained to discriminate between IP administered 1.0 g/kg (10% v/v) saline under a sweetened milk-reinforced fixed ratio 10 (FR10) schedule reinforcement. When animals met criteria, antagonism tests conducted with (0.3-10.0 mg/kg, IP) (15.0-60.0 IP). Neither nor antagonized ethanol-mediated effects. addition, (3.0-300.0 did not substitute These results indicate least certain complex do attenuate interoceptive cue rat.
sci-hub.se 参考文章(49)
Ian P. Chessell, Andrew W. Procter, Paul T. Francis, David M. Bowen, d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain Brain Research. ,vol. 565, pp. 345- 348 ,(1991) , 10.1016/0006-8993(91)91668-Q
Steven R. Goldberg, Ian P. Stolerman, Behavioral Analysis of Drug Dependence ,(1986)
Nathan Back, Sydney Spector, Modern methods in pharmacology A.R. Liss ; Wiley-Liss. ,(1982)
Elizabeth W. Anthony, Mark E. Nevins, Anxiolytic-like effects of N-methyl-D-aspartate-associated glycine receptor ligands in the rat potentiated startle test. European Journal of Pharmacology. ,vol. 250, pp. 317- 324 ,(1993) , 10.1016/0014-2999(93)90397-Z
William F. Hood, Robert P. Compton, Joseph B. Monahan, D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neuroscience Letters. ,vol. 98, pp. 91- 95 ,(1989) , 10.1016/0304-3940(89)90379-0
Jouni Sirviö, Tommi Ekonsalo, Paavo Riekkinen, Hannele Lahtinen, Paavo Riekkinen, D-cycloserine, a modulator of the N-methyl-D-aspartate receptor, improves spatial learning in rats treated with muscarinic antagonist. Neuroscience Letters. ,vol. 146, pp. 215- 218 ,(1992) , 10.1016/0304-3940(92)90081-H
Jo Ellen Dildy-Mayfield, Steven W. Leslie, Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol. Journal of Neurochemistry. ,vol. 56, pp. 1536- 1543 ,(1991) , 10.1111/J.1471-4159.1991.TB02048.X
Joseph B. Monahan, Gail E. Handelmann, William F. Hood, Alexis A. Cordi, D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats Pharmacology, Biochemistry and Behavior. ,vol. 34, pp. 649- 653 ,(1989) , 10.1016/0091-3057(89)90571-6
R.J. Fishkin, E.S. Ince, W.A. Carlezon, R.W. Dunn, D-cycloserine attenuates scopolamine-induced learning and memory deficits in rats. Behavioral and Neural Biology. ,vol. 59, pp. 150- 157 ,(1993) , 10.1016/0163-1047(93)90886-M
Rueben A. Gonzales, Laurie M. Brown, Brain regional differences in glycine reversal of ethanol-induced inhibition of n-methyl-d-aspartate-stimulated neurotransmttter release Life Sciences. ,vol. 56, pp. 571- 577 ,(1995) , 10.1016/0024-3205(94)00489-F